Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian regions, 2007-2008.
نویسندگان
چکیده
Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. In 2007 and 2008, this Gonococcal Antimicrobial Surveillance Programme (GASP) was enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitment of additional centres within the WPR. Approximately 17,450 N. gonorrhoeae were examined for their susceptibility to one or more antibiotics used for the treatment of gonorrhoea by external quality controlled methods in 24 reporting centres in 20 countries and/or jurisdictions. A high proportion of penicillin and/or quinolone resistance was again detected amongst isolates tested in North Asia and the WHO SEAR, but much lower rates of penicillin resistance and little quinolone resistance was present in most of the Pacific Island countries. The proportion of gonococci reported as 'resistant', 'less susceptible' or 'non-susceptible' gonococci to the third-generation cephalosporin antibiotic ceftriaxone lay in a wide range, but no major changes were evident in cephalosporin minimal inhibitory concentration (MIC) patterns in 2007-2008. Altered cephalosporin susceptibility was associated with treatment failures following therapy with oral third-generation cephalosporins. There is a need for revision and clarification of some of the in vitro criteria that are currently used to categorise the clinical importance of gonococci with different ceftriaxone and oral cephalosporin MIC levels. The number of instances of spectinomycin resistance remained low. A high proportion of strains tested continued to exhibit a form of plasmid mediated high level resistance to tetracyclines. The continuing emergence and spread of antibiotic resistant gonococci in and from the WHO WPR and SEAR supports the need for gonococcal antimicrobial resistance surveillance programs such as GASP to be maintained and potentially expanded.
منابع مشابه
Surveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific and South East Asian Regions, 2009.
Long-term surveillance of antimicrobial resistance in Neisseria gonorrhoeae has been conducted in the World Health Organization (WHO) Western Pacific Region (WPR) to optimise antibiotic treatment of gonococcal disease since 1992. From 2007, the Gonococcal Antimicrobial Surveillance Programme (GASP) has been enhanced by the inclusion of data from the South East Asian Region (SEAR) and recruitmen...
متن کاملSurveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 1999. The WHO Western Pacific Region Gonococcal Antimicrobial Surveillance Programme.
A long-term programme of surveillance of antimicrobial resistance in Neisseria gonorrhoeae isolated in the World Health Organization's Western Pacific Region Gonococcal Antimicrobial Surveillance Programme ((WHO WPR GASP) continued in 1999. Over 10,000 gonococci were examined in 18 focal centres. Resistance to the quinolones and penicillins was already high in many parts of the Western Pacific ...
متن کاملSurveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 2006.
The World Health Organization Western Pacific Region Gonococcal Antimicrobial Surveillance Programme (WHO WPR GASP) examined approximately 8,400 isolates of Neisseria gonorrhoeae from 16 countries for resistance to relevant antibiotics in 2006. Antimicrobial resistance was at record levels in the region and poses major problems for the management of this important disease. High rates of resista...
متن کاملSurveillance of antibiotic resistance in Neisseria gonorrhoeae in the WHO Western Pacific Region, 1998. The WHO Western Pacific Gonococcal Antimicrobial Surveillance Programme.
Effective treatment of gonorrhoea in the World Health Organization's Western Pacific Region is hampered by the emergence and spread of antibiotic resistant strains of Neisseria gonorrhoeae. A programme of surveillance of gonococcal susceptibility to antibiotics (GASP) continued in the region in 1998. A high proportion of isolates in many participating countries was resistant to quinolones and p...
متن کاملAn outbreak of hepatitis A associated with a spa pool.
Pacific Region Gonococcal Surveillance Programme. 1994 Annual report. Comm Dis Intell 1995;19:495-499. 5. The World Health Organization Western Pacific Region Gonococcal Antimicrobial Surveillance Programme. Antimicrobial resistance in gonococci, Western Pacific Region, 1995. Comm Dis Intell 1996;20:425-428. 6. The World Health Organization Western Pacific Region Gonococcal Antimicrobial Survei...
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ورودعنوان ژورنال:
- Communicable diseases intelligence quarterly report
دوره 34 1 شماره
صفحات -
تاریخ انتشار 2010